Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High-Throughput Oligonucleotide Probe Array Analysis
نویسندگان
چکیده
منابع مشابه
Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High-Throughput Oligonucleotide Probe Array Analysis
Human leukocyte antigens (HLA) are important biomarkers because multiple diseases, drug toxicity, and vaccine responses reveal strong HLA associations. Current clinical HLA typing is an elimination process requiring serial testing. We present an alternative in situ synthesized DNA-based microarray method that contains hundreds of thousands of probes representing a complete overlapping set cover...
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Renal transplantation remains the best option for patients suffering from end stage renal disease (ESRD). Given the worldwide shortage of organs and growing population of patients with ESRD, those waitlisted for a transplant is ever expanding. Contemporary crossmatch methods and human leukocyte antigen (HLA) typing play a pivotal role in improving organ allocation and afford better matches to r...
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Background: Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. Although cathepsin C (CTSC) gene mutations have been established in about 70-80% of PLS patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. Objective: To assess the associat...
متن کامل[Human leukocyte antigen typing proficiency surveys in Korea, 2005-2006].
BACKGROUND To monitor the performance of histocompatibility testing laboratories, HLA proficiency survey in Korea has been conducted biannually since 1996. In this report, we summarized the results of the surveys performed in recent two years (2005-2006). METHODS A total of four proficiency surveys were performed, in which 59-61 laboratories participated. Each survey included three tests for ...
متن کاملHuman leukocyte antigen typing in Iraqi multiple sclerosis patients.
OBJECTIVE To assess the relative frequency of human leukocyte antigen (HLA) class I and class II in Iraqi multiple sclerosis (MS) patients, and to ascertain whether they offer any etiologic or protective role. METHODS We conducted this study in the Baghdad MS Clinic and Teaching Laboratory Institute, Medical City, Baghdad Teaching Hospital, Baghdad, Iraq from March to July 2004. We enrolled 4...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2014
ISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00597